DBT has taken up the initiative to address MDR-TB in NER through “MDR-TB in North East India: A Genomic Driven Approach" programme



Tuberculosis is one of the India’s major health problems. In spite of the commendable performance of National TB control programme, the incidence of TB has not declined significantly. With the emergence of MDR-TB, a different set of challenges and problems in the public health programme has set in. These challenges are even more daunting in the Northeast India, underlining the need to develop innovative intervention approaches. Due to varied geographical and ethnic diversity of North Eastern Region of India, the genetic makeup, transmission dynamics, virulence and drug resistance patterns of Mycobacterium strains circulating in this region need to be studied in depth so as to find ways to mitigate the TB situation.
Therefore, DBT initiated “MDR-TB in North East India: A Genomic Driven Approach." to address various scientific and societal issues of MDR-TB in NER and devise a long-term plan for disease management. This network programme involves scientists from the State Government Departments, NGO, Institutions and Universities of the Eight North Eastern Region and from other parts of the country.
Even as the incidence of TB has not declined significantly in spite of several initiatives by the government, especially in the North Eastern Region (NER) of the country, the Department of Biotechnology (DBT) is embarking on a research programme in a consortium mode on MDR-TB in the NER with focus on genomics driven intervention approaches.
The broad areas of this joint research programme include, Mapping hot-spots of TB and MDR/XDR-TB in NER by whole genome sequencing of mycobacterium tuberculosis isolates (this will include development/validation of media/device for cold chain transport of TB isolates across NER and other parts of the country); Population genetic studies to delineate predisposing factors associated with TB/MDR-TB/XDR-TB, including pharmacogenomics of anti-TB drugs; Repurposing studies on existing drugs against other diseases for their anti-TB activity. Relook into critical concentrations of drugs that define sensitive and resistant M. tuberculosis strains; Development/validation of new tools for diagnosis of TB and drug resistant TB and non-tuberculosis mycobacterium (NTM), creation of infrastructure facility in NER; and Awareness programme on NTMs and paragonimiasis through training/seminar/workshop/health camps.
Researchers from universities, institutes, colleges, hospitals, health departments and NGOs having experience in these areas can participate in this research programme.
DBT has taken up the initiative to address various scientific and societal issues of MDR-TB in NER and devise a long-term plan for disease management.


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